MA · Northeast
Boston / Cambridge venture capital & startups
Boston–Cambridge biotech creation, AI biology, and enterprise — General Catalyst, Third Rock, Atlas, F-Prime, CRV, Battery, Spark, ARCH syndicates.
Greater Boston is the US biotech capital with Cambridge HQ density (General Catalyst, Atlas, F-Prime, CRV) and Boston creation shops (Third Rock, Battery). Curated startups include Boltz, OpenEvidence, Whoop, GC Therapeutics, Dyno Therapeutics, Rome Therapeutics, and Asimov.
Aliases: boston, cambridge, somerville, waltham, lexington, massachusetts. Funds matched by HQ; startups by hq field plus curated IDs.
Venture firms in Boston / Cambridge
Matched from fund headquarters in our directory (alias-based). Dual-HQ firms may appear in more than one city.
| Firm | HQ (directory) | Leads |
|---|---|---|
| General Catalyst | — | |
| Third Rock Ventures | — | |
| Atlas Venture | — | |
| F-Prime Capital | — | |
| CRV | — | |
| Battery Ventures | — | |
| Spark Capital | — | |
| ARCH Venture Partners | — | |
| Atreides Management | Boston, Massachusetts, United States | — |
| Clean Energy Ventures | Boston, United States | — |
| Fidelity Management & Research Company | Boston, United States | — |
| Spectrum Equity | Boston, San Francisco and London | Growth |
| Volition Capital | Boston, Massachusetts, United States | — |
| Wellington Management | Boston, United States | — |
Startups we cover in Boston / Cambridge
Matched from startup hq fields. Many profiles still lack HQ — curated lists
in editorial notes fill gaps when verified.
| Startup | One-liner | HQ |
|---|---|---|
| Boltz | — | |
| OpenEvidence | — | |
| WHOOP | — | |
| GC Therapeutics | — | |
| Dyno Therapeutics | — | |
| ROME Therapeutics | — | |
| Asimov | — | |
| Curie.Bio | — | |
| Aktis Oncology | Clinical-stage radiopharmaceutical biotech targeting solid tumors with alpha emitters. | Boston, Massachusetts |
| Backflip AI | Generative AI platform that turns text and images into 3D-printable models. | Boston, MA |
| Catena Labs | AI-native financial infrastructure for autonomous agents — wallets, payments, and compliance rails. | Boston, Massachusetts |
| Knownwell | Weight-inclusive primary and metabolic health clinics—hybrid virtual plus in-person obesity care. | Boston, Massachusetts |
| Ledgebrook | AI-native specialty insurance underwriting platform for wholesale brokers | Boston, Massachusetts, United States |
| Modulate | Audio-native AI company that raised $25 million in new funding led by Future Ventures. | Boston, Massachusetts, USA |
| PatientPing | National ADT care-coordination network, now part of Bamboo Health after Appriss Health acquisition. | Boston, MA |
| Quantopian | Crowdsourced algo-trading platform that shut down in 2020 after its hedge fund underperformed. | Boston, MA |
| Starburst | Enterprise Trino SQL engine for querying data without moving it to a warehouse. | Boston, Massachusetts |
| WhiteLab Genomics | TechBio company using AI to design delivery systems and genetic payloads for genomic medicines. | Paris, France and Boston, Massachusetts, United States |
| Xapien | AI-native due diligence that turns open-web and registry risk into sourced reports in minutes. | London, United Kingdom (Boston expansion) |
| Zus Health | Shared health data platform giving digital health builders a common patient record (ZAP). | Boston, MA |
Coverage gaps
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Flagship Therapeutics / Moderna-era creation cohort
Named in ecosystem playbooks — not all have /startup/ pages yet
-
Boston cyber / defense SaaS
Under-indexed vs biotech in our startup JSON
-
Harvard vs MIT spinout long tail
Honest gap — we curate verified profiles only
Related reading
Boston / Cambridge FAQs
Practical answers for founders researching this investor.