Birmingham city hub: 10 funds and 6 startups matched from our directory. Healthcare services tech and Southeast digital health.
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AL · South

Birmingham venture capital & startups

Birmingham, Alabama healthcare and marketplace map — Shipt’s Target exit, Acclinate and ArcheHealth raises, UAB spinouts, and local funds that write first checks.

Birmingham is a Southeast healthcare-services build site: UAB research, large health systems, and Blue Cross Blue Shield of Alabama adjacency. We profile Shipt’s $550M Target exit, active digital-health companies (Acclinate, ArcheHealth), UAB-linked Dialytix and TIXiMED, Prosper relocators, and Birmingham funds including First Avenue Ventures, 450 Ventures, Prosper HealthTech, Measured Capital, and Bronze Valley.

Funds matched

10

Startups matched

6

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Alabama Birmingham only (not Birmingham, UK). Funds matched by headquarters aliases plus curated national capital listed in the related article. Startups matched by hq field (Birmingham, AL) and curated IDs.

Venture firms in Birmingham

Matched from fund headquarters in our directory (alias-based). Dual-HQ firms may appear in more than one city.

Firm HQ (directory) Leads
First Avenue Ventures Birmingham, AL Pre-Seed, Seed
450 Ventures Birmingham, AL —
Prosper HealthTech Accelerator Birmingham, AL Pre-Seed, Seed
Measured Capital Birmingham, AL Pre-Seed, Seed
Bronze Valley Birmingham, AL Pre-Seed, Seed
Alabama Futures Fund Birmingham, AL Seed
Define Ventures San Francisco, CA Series A
F-Prime Capital Cambridge, MA Series A, Series B+
Bessemer Venture Partners New York, NY Seed, Series A, Series B+
General Catalyst Cambridge, MA Series A, Series B+

Startups we cover in Birmingham

Matched from startup hq fields. Many profiles still lack HQ — curated lists in editorial notes fill gaps when verified.

Startup One-liner HQ
Shipt Same-day grocery and retail delivery marketplace founded in Birmingham; acquired by Target. Birmingham, AL
Acclinate Digital health equity platform using NOWINCLUDED community engagement and AI to improve clinical trial diversity. Birmingham, AL
ArcheHealth AI operational intelligence platform that shows hospitals the true patient-level cost of care. Birmingham, AL
Dialytix UAB spinout Kidney Cloud platform for real-time kidney disease care management and dialysis ops. Birmingham, AL
Revella Health AI and clinical outreach for Medicare Advantage Stars, risk adjustment, and care-gap closure. Birmingham, AL
TIXiMED UAB spinout developing TIX100, an oral TXNIP inhibitor for Type 1 diabetes. Birmingham, AL

Coverage gaps

  • Innovation Depot programs (Voltage / Boost)

    Primary downtown incubator campus — ecosystem home base, not a classic /fund/ VC vehicle

  • Pack Health (historical)

    Major Birmingham healthtech exit to Quest (~$123M, 2022); unit later shut by Quest in 2025 — track as history, not an active profile

  • Archimedes Vascular / ImmPrev Bio

    First Avenue life-science portfolio names worth future /startup/ pages when we expand medtech depth

  • Harbert Growth Partners

    Birmingham-parent growth equity — different product than seed; optional future /fund/ coverage

Related reading

Birmingham FAQs

Practical answers for founders researching this investor.

Local profiles include First Avenue Ventures, 450 Ventures, Prosper HealthTech Accelerator, Measured Capital, and Bronze Valley. National digital-health firms such as Define Ventures, F-Prime Capital, Bessemer, and General Catalyst are shortlisted by thesis for later rounds. See /vc/birmingham-al.
Shipt, Acclinate, ArcheHealth, Dialytix, Revella Health, and TIXiMED. Browse /vc/birmingham-al for live matches.
Raise with healthcare buyer proof (system pilots, payer metrics) and early local capital, then shortlist national digital-health or multi-stage firms from /directory for Series A+.
Seed and accelerator capital lean local (First Avenue, Prosper, Bronze Valley, Measured). Growth capital for Alabama companies usually comes from national multi-stage firms.