Investor profile for Define Ventures: stage-based planning range, investment stages, sector focus, portfolio companies, sources, and verification status. Part of the Venture Capital Tracker directory.
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Define Ventures stages, portfolio and investment profile

San Francisco digital-health venture firm founded in 2020 by Lynne Chou O'Keefe (formerly Kleiner Perkins). One of the larger early-stage funds focused exclusively on health tech—from incubation and seed through Series B.

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Stage-based planning range

$1M–$10M

This is a planning range inferred from stage coverage, not a firm-disclosed check size.

Methodology: Stage bucket inferred from the rounds a fund leads or invests in.

No firm-specific check-size disclosure is recorded.

Source link not recorded Confidence: 25% Verified: Not recorded View methodology

Investment stages

Leads: Series A

Participates: Seed, Series A, Series B+

Sector focus

Healthtech · Biotech & Life Sciences

Geography

San Francisco, CA

Founded 2018

Fund size / AUM

Not recorded

A separate fund-size evidence record is not yet available.

Portfolio in our directory

None yet

Linked startup profiles

Latest fund vehicle

Not recorded

Vehicle name, size, and vintage are not yet structured.

Recent tracked investment

Not recorded

No dated round explicitly links this fund.

Rounds they lead

Series A

Rounds they invest

Seed Series A Series B+

Last verified: Not recorded. Check-size evidence is labeled by basis so planning estimates are not presented as firm disclosures.

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FAQs about Define Ventures

Stage fit, check size, thesis, and how founders typically approach this firm — based on public sources and our directory.

Per our directory, Define leads Series A rounds and invests from seed through Series B+. The firm also incubates companies—spinning out digital-health businesses from scratch when the thesis warrants it.
Define's debut fund targeted checks from roughly $750K to $6M across 15–18 investments, per public reporting at launch. Later funds are larger; exact sizing varies by stage. The firm does not publish one fixed check for every deal.
Define is headquartered in San Francisco. It primarily backs U.S. digital-health companies, with portfolio exposure across care delivery, benefits, and life-sciences tools serving American healthcare markets.
Our directory tags healthtech and biotech/life sciences. Define invests exclusively in digital health—telemedicine, care navigation, employer benefits, clinical research, and health-system transformation—not generalist software or crypto.
Define leads Series A rounds and incubations, and co-invests at seed and Series B. Lynne Chou O'Keefe has led deals in companies like Hims, Tia, and Lightship, positioning Define as a conviction health-tech partner.
We do not currently have startups in our directory with Define Ventures listed as an investor. Public portfolio names include Hims, Tia, Folx Health, and DexCare—many not yet profiled on Venture Capital Tracker.
Digital-health founders at seed or Series A can engage through defineventures.com (also definevc.com). Warm introductions from health-system operators, portfolio founders, or healthcare-focused angels help. Define looks for teams transforming how care is delivered, paid for, or researched.
We do not yet have a dedicated Define Ventures fund article. The firm raised $460M across Fund III and an Opportunities Fund (2023), per public reporting—one of the largest early-stage digital-health pools.
Website

By Venture Capital Tracker

Editorial note: AI tools assisted with research, structure, or drafting. Venture Capital Tracker retains human editorial responsibility for factual accuracy, relevance, and source quality before publication.