Investor profile for Define Ventures: typical check size, headquarters (San Francisco, CA), stages they lead or invest in, and links to website and social profiles. Part of the Venture Capital Tracker directory.
San Francisco digital-health venture firm founded in 2020 by Lynne Chou O'Keefe (formerly Kleiner Perkins). One of the larger early-stage funds focused exclusively on health tech—from incubation and seed through Series B.
Stage fit, check size, thesis, and how founders typically approach this firm — based on public sources and our directory.
Per our directory, Define leads Series A rounds and invests from seed through Series B+. The firm also incubates companies—spinning out digital-health businesses from scratch when the thesis warrants it.
Define's debut fund targeted checks from roughly $750K to $6M across 15–18 investments, per public reporting at launch. Later funds are larger; exact sizing varies by stage. The firm does not publish one fixed check for every deal.
Define is headquartered in San Francisco. It primarily backs U.S. digital-health companies, with portfolio exposure across care delivery, benefits, and life-sciences tools serving American healthcare markets.
Our directory tags healthtech and biotech/life sciences. Define invests exclusively in digital health—telemedicine, care navigation, employer benefits, clinical research, and health-system transformation—not generalist software or crypto.
Define leads Series A rounds and incubations, and co-invests at seed and Series B. Lynne Chou O'Keefe has led deals in companies like Hims, Tia, and Lightship, positioning Define as a conviction health-tech partner.
We do not currently have startups in our directory with Define Ventures listed as an investor. Public portfolio names include Hims, Tia, Folx Health, and DexCare—many not yet profiled on Venture Capital Tracker.
Digital-health founders at seed or Series A can engage through defineventures.com (also definevc.com). Warm introductions from health-system operators, portfolio founders, or healthcare-focused angels help. Define looks for teams transforming how care is delivered, paid for, or researched.
We do not yet have a dedicated Define Ventures fund article. The firm raised $460M across Fund III and an Opportunities Fund (2023), per public reporting—one of the largest early-stage digital-health pools.
